Clarity Submit Skill

Submit protein variant hypotheses to Clarity Protocol for automated validation and ColabFold structural prediction.

Quick Start

Submit a hypothesis:

python scripts/submit_hypothesis.py --protein SOD1 --variant A4V --rationale "ALS-linked mutation with unknown structural impact"

Submit with optional fields:

python scripts/submit_hypothesis.py --protein MAPT --variant P301L --rationale "Tau pathology in frontotemporal dementia" --wallet "YOUR_SOLANA_WALLET"

Check hypothesis status:

python scripts/check_status.py --id 42

Setup

Set your write API key:

export CLARITY_WRITE_KEY=your_write_key_here

Contact the Clarity Protocol team to request a write API key.

What Happens After Submission

1. Feasibility validation runs automatically against UniProt, ClinVar, gnomAD, and PubMed
2. If validated, the hypothesis is auto-queued for ColabFold structural prediction
3. Four AI research agents continuously monitor the variant for new findings
4. Results are available at the tracking URL returned after submission

Request Fields

• --protein (required): Protein name (e.g., SOD1, MAPT, APP, SNCA)
• --variant (required): Variant notation (e.g., A4V, P301L, G2019S)
• --rationale (required): Why this variant is worth investigating (min 10 characters)
• --disease (optional): Disease area (auto-detected from protein if omitted)
• --wallet (optional): Solana wallet address for $FOLD reward eligibility

Response Fields

• id: Unique hypothesis identifier
• protein_name: Normalized protein name
• variant_notation: Variant as submitted
• status: Current status (submitted, validating, validated, queued, folding, complete, rejected)
• tracking_url: URL to track progress on clarityprotocol.io

Rate Limits

• Write (POST): 10 submissions per day per key
• Read (GET): 100 requests per minute per key

Size Limits

Proteins up to 1,500 residues can be folded. Larger proteins (e.g., LRRK2 at 2,527 residues) exceed hardware capacity and will be rejected during validation.

Error Handling

403 Forbidden: Invalid or missing write API key. Set CLARITY_WRITE_KEY env var.

422 Validation Error: Invalid input (protein name empty, rationale too short, etc.).

429 Rate Limit: You've exceeded 10 submissions/day. Wait until tomorrow.

Use Cases

• Programmatically submit variants for investigation
• Integrate Clarity Protocol into research pipelines
• Batch submission of variants of interest
• Agent-driven hypothesis generation and submission