Harsh

This command will complete a comprehensive and brutally honest critical review of your manuscript. The review identifies major methodological flaws and areas where the work falls short of publication standards for a high-impact clinical journal.

When to use

• When preparing a manuscript for submission to a high-impact clinical journal

• When you need honest feedback about methodological weaknesses

• When you want to identify publication-blocking issues before submission

• When seeking to improve the scientific rigor of your work

Instructions

• Read the README.md and CLAUDE.md to understand the project purpose, setup instructions, and key information

• Provide a concise overview of the project based on the gathered context

• Focus on ./result and ./manuscripts

• Save the harsh critical comment in the ./docs/

• Give a plan to fix the problem that will contributing meaningful biological insights